Title: Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma (ACADIA)
Brief Description: Comparing Albuterol v. Albuterol + Budesonide
Sponsor: AstraZeneca
PI: Sankaran Krishnan
Learn more: https://clinicaltrials.gov/study/NCT06307665?term=acadia&rank=1
Title: A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma. (EXHALE-2)
Brief Description: New Oral Agent for Asthma
Sponsor: Areteia Therapeutics
PI: Sankaran Krishnan
Learn more: https://clinicaltrials.gov/study/NCT05763121?term=exhale-2&rank=1
Title: Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma (FLASH)
Brief Description: New Anti-inflammatory for Asthma
Sponsor: AstraZeneca
PI: Sankaran Krishnan
Learn more: https://clinicaltrials.gov/study/NCT05251259?term=astrazeneca%20flash&rank=1
Title: Efficacy and Safety of Subcutaneous Dupilumab in Participants With Asthma/ Asthmatic Wheeze Aged 2 to <6 Years (LIBERTY ASTHMA TREKIDS)
Brief Description: Biologic for 2-5 Year Olds
Sponsor: Sanofi
PI: Sankaran Krishnan
Learn more: https://clinicaltrials.gov/study/NCT06191315?term=trekids&rank=1
Title: Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/ Long-acting Beta-agonist (ICS/ LABA) in Comparison to ICS Dose Escalation to High Dose ICS/ LABA in Adolescent and Adult Patients With Uncontrolled Asthma (AIM4:Next Step)
Brief Description: Biologic Added to Medium Dose Controller Medication v. High Dose Controller Medication Alone
Sponsor: Regeneron
PI: Sankaran Krishnan
Learn more: https://clinicaltrials.gov/study/NCT06572228?term=R668-AS-2373&rank=1
Title: A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/ Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
Brief Description: Albuterol v. Albuterol + Fluticasone
Sponsor: Teva Pharmaceuticals
PI: Allen Dozor
Learn more: https://clinicaltrials.gov/study/NCT06052267?term=FpA-AS-30094&rank=1
Title: A Phase 1 Study Evaluating Safety and Tolerability of RCT2100 in Healthy Participants and in Participants With CF
Brief Description: New mRNA Therapy for CF
Sponsor: ReCode Therapeutics
PI: Allen Dozor
Learn more: https://clinicaltrials.gov/study/NCT06237335?term=rct2100&rank=1
Title: Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study (STOP360AG)
Brief Description: 1 IV Antibiotic v. 2 IV Antibiotics for treatment of Pulmonary Exacebation with Pseudomonas
Sponsor: Cystic Fibrosis Foundation
PI: Allen Dozor
Learn more: https://clinicaltrials.gov/study/NCT05548283?term=stop-360&rank=1
Title: Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF
Brief Description: Observational Study For People With CF
Sponsor: Cystic Fibrosis Foundation
PI: Allen Dozor
Learn more: https://clinicaltrials.gov/study/NCT05639556?term=strong-cf&rank=1
Title: A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators
Brief Description: Observational Study For People With CF Not Taking Modulators
Sponsor: Cystic Fibrosis Foundation
PI: John Welter
Learn more: https://clinicaltrials.gov/study/NCT06504589?term=REACH-OB-23&rank=1
Title: A Study to Evaluate the Safety of CMTX-101 in People with Cystic Fibrosis
Brief Description: New IV Drug for People With CF with Pseudomonas
Sponsor: Clarametyx Biosciences
PI: John Welter
Learn more: https://clinicaltrials.gov/study/NCT06159725?term=CMTX101&rank=2
Title: Study of Oral Upadacitinib and Subcutaneous/ Intravenous Tocilizumab to Evaluate Change in Disease Activity, Adverse Events and How Drug Moves Through the Body of Pediatric and Adolescent Participants With Active Systemic Juvenile Idiopathic Arthritis. (SELECT-sJIA)
Brief Description: Comparing Two Biologics for Systemic Juvenile Idiopathic Arthritis
Sponsor: AbbVie
PI: Christine Hom
Learn more: https://clinicaltrials.gov/study/NCT05609630?term=m14682&rank=1
Title: A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab (KnaPsAck)
Brief Description: Comparing Two Biologics for Juvenile Psoriatic Arthritis
Sponsor: AbbVie
PI: Christine Hom
Learn more: https://clinicaltrials.gov/study/NCT06100744?term=m23732&rank=1
Title: A Phase 2 Basket Study of Vosoritide in Children With Turner Syndrome, SHOX Deficiency and Noonan Syndrome With an Inadequate Response to Human Growth Hormone
Brief Description: Comparing Two Types of Growth Hormone for Children with Turner, SHOX, or Noonan
Sponsor: BioMarin Pharmaceutical
PI: Shilpa Mehta
Learn more: https://clinicaltrials.gov/study/NCT06668805?term=111-211&rank=2